Basic Information
| LncRNA/CircRNA Name | CRNDE |
| Synonyms | CRNDE, CRNDEP, LINC00180, NCRNA00180, PNAS-108, lincIRX5 |
| Region | GRCh38_16:54845189-54929189 |
| Ensemble | ENSG00000245694 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | intrahepatic cholangiocarcinoma |
| ICD-0-3 | C22 |
| Methods | qPCR, Western blot, in vitro knockdown etc. |
| Sample | IHCC tissues, IHCC cell lines (HuCCT1, RBE, HCCC9810 and HUH28) |
| Expression Pattern | up-regulated |
| Function Description | CRNDE ectopic expression in HCCC9810 cells promoted proliferation. Moreover, the migration and invasion of HuCCT1 cells were greatly repressed with CRNDE deficiency following Transwell and Matrigel assays. Accordingly, the motility of HCCC9810 cells was notably accelerated with CRNDE overexpression. Mechanistically, CRNDE was revealed to facilitate the epithelial-mesenchymal transition (EMT) of IHCC cells. CRNDE could promote the clinical progression and metastasis of IHCC by facilitating EMT. CRNDE may be a novel prognostic marker and therapeutic target in IHCC.High CRNDE expression was identified as an independent risk factor of IHCC poor OS and PFS. |
| Pubmed ID | 29556285 |
| Year | 2018 |
| Title | Overexpression of long non-coding RNA CRNDE facilitates epithelial-mesenchymal transition and correlates with poor prognosis in intrahepatic cholangiocarcinoma. |
External Links
| Links for CRNDE | GenBank HGNC NONCODE |
| Links for intrahepatic cholangiocarcinoma | OMIM COSMIC |