Basic Information
| LncRNA/CircRNA Name | CRNDE |
| Synonyms | CRNDE, CRNDEP, LINC00180, NCRNA00180, PNAS-108, lincIRX5 |
| Region | GRCh38_16:54845189-54929189 |
| Ensemble | ENSG00000245694 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR |
| Sample | breast cancer tissues, cell lines (MCF-7, MDA-MB-231, MDA-MB-468 and BT-549) |
| Expression Pattern | up-regulated |
| Function Description | CRNDE expression is remarkably up-regulated in BC tissue specimens and cell lines in comparison to corresponding normal tissues and normal human breast epithelial cells. Up-regulated CRNDE expression was greatly associated with larger tumor size, advanced TNM stage and unfavorable prognosis of BC patients. We uncovered that miR-136 is a bona fide binding target of CRNDE, and that up-regulation of CRNDE promoted the mRNA and protein expressions of B-catenin, c-myc and cyclinD1. |
| Pubmed ID | 28469804 |
| Year | 2017 |
| Title | Long noncoding RNA CRNDE activates Wnt/B-catenin signaling pathway through acting as a molecular sponge of microRNA-136 in human breast cancer |
External Links
| Links for CRNDE | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |