Basic Information
| LncRNA/CircRNA Name | CRNDE |
| Synonyms | CRNDE, CRNDEP, LINC00180, NCRNA00180, PNAS-108, lincIRX5 |
| Region | GRCh38_16:54845189-54929189 |
| Ensemble | ENSG00000245694 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | medulloblastoma |
| ICD-0-3 | NA |
| Methods | qPCR, Flow cytometry assay etc. |
| Sample | medulloblastoma tissues, cell lines (D283, Daoy, D425, D341, D458) |
| Expression Pattern | up-regulated |
| Function Description | Our data suggest that transcript levels of CRNDE are elevated in clinical medulloblastoma tissues instead of in adjacent non-cancerous tissues. Knockdown of CRNDE significantly slowed cell proliferation rates and inhibited colony formation in Daoy and D341 cells. Tumor growth in vivo was also inhibited after CRNDE knockdown. |
| Pubmed ID | 27383309 |
| Year | 2016 |
| Title | Long non-coding RNA CRNDE promotes tumor growth in medulloblastoma. |
External Links
| Links for CRNDE | GenBank HGNC NONCODE |
| Links for medulloblastoma | OMIM COSMIC |