Basic Information
| LncRNA/CircRNA Name | CRNDE |
| Synonyms | CRNDE, CRNDEP, LINC00180, NCRNA00180, PNAS-108, lincIRX5 |
| Region | GRCh38_16:54845189-54929189 |
| Ensemble | ENSG00000245694 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot |
| Sample | tumor tissues, colorectal cancer cell lines (DLD1,HCT116,SW480,LOVO) |
| Expression Pattern | up-regulated |
| Function Description | In conclusion, our data suggest that the lncRNA CRNDE promotes the progression of CRC and is a potential therapeutic target for CRC intervention. However, the above studies have singly pointed that CRNDE plays an oncogene function by regulating miRNA. The more effective and complex mechanisms of CRNDE deserve further study. |
| Pubmed ID | 28796262 |
| Year | 2017 |
| Title | Long noncoding RNA CRNDE promotes colorectal cancer cell proliferation via epigenetically silencing DUSP5/CDKN1A expression. |
External Links
| Links for CRNDE | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |