Basic Information
| LncRNA/CircRNA Name | CTA-941F9.9 |
| Synonyms | NA |
| Region | GRCh38_22:45604432-45605621 |
| Ensemble | ENSG00000238120 |
| Refseq | NR_131244 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qPCR, Western blot, in vitro knockdown |
| Sample | CRC cell lines (HCT116, HT29, and RKO, SW620 and SW480, one normal colonic epithelial cell line FHC cells, CRC tissues and NATs |
| Expression Pattern | down-regulated |
| Function Description | lncRNA CTA-941F9.9 to be significantly downregulated in CRC tissues in both cohorts, with areas under the ROC curve (AUC) of 0.802 and 0.876. However, no significant correlations between CTA-941F9.9 ex- pression levels and clinicopathological characteristics or patient outcomes were observed. We also found that CTA-941F9.9 promotes autophagy in CRC cell lines but no significant function of CTA-941F9.9 in regulating cancer cell proliferation or migration. |
| Pubmed ID | 31343781 |
| Year | 2019 |
| Title | The long noncoding RNA CTA-941F9.9 is frequently downregulated and may serve as a biomarker for carcinogenesis in colorectal cancer |
External Links
| Links for CTA-941F9.9 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |