Basic Information
| LncRNA/CircRNA Name | CTBP1-AS |
| Synonyms | CTBP1-AS, PCAT10 |
| Region | GRCh38_4:1210120-1218591 |
| Ensemble | ENSG00000280927 |
| Refseq | NR_104331 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qPCR, Western blot, Northern blot, RIP etc. |
| Sample | prostate cancer tissues, cell lines (VCaP, LNCaP, DU145, RWPE etc.) |
| Expression Pattern | up-regulated |
| Function Description | CTBP1-AS is predominantly localized in the nucleus and its expression is generally upregulated in prostate cancer. CTBP1-AS promotes both hormone-dependent and castration-resistant tumour growth. Mechanistically, CTBP1-AS directly represses CTBP1 expression by recruiting the RNA-binding transcriptional repressor PSF together with histone deacetylases. CTBP1-AS also exhibits global androgen-dependent functions by inhibiting tumour-suppressor genes via the PSF-dependent mechanism thus promoting cell cycle progression. |
| Pubmed ID | 23644382 |
| Year | 2013 |
| Title | Androgen-responsive long noncoding RNA CTBP1-AS promotes prostate cancer. |
External Links
| Links for CTBP1-AS | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |