Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | NA |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR , in vitro knockdown etc |
| Sample | NSCLC Tissues,cell lines (A549,SPCA1, H1299, and H358) |
| Expression Pattern | up-regulated |
| Function Description | LncRNA DANCR was upregulated in NSCLC. The knockdown of lncRNA DANCR inhibited cell proliferation and accelerated cell apoptosis in NSCLC. LncRNA DANCR interacted with miR-214-5p. MiR-214-5p over-expression partially reversed the regulatory effects of DANCR on proliferation and apoptosis in NSCLC. In addition, CIZ1 was the downstream gene binding miR-214-5p. LncRNA DANCR could regulate the miR-214-5p/CIZ1 axis. |
| Pubmed ID | 32196604 |
| Year | 2020 |
| Title | Upregulation of lncRNA DANCR Functions as an Oncogenic Role in Non-Small Lung Cancer by Regulating miR-214-5p/CIZ1 Axis |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |