Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | differentiation antagonizing nonprotein coding RNA |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | autophagy/apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, Western blot, Luciferase reporter assay, RIP |
| Sample | primary osteosarcoma samples,MG-63, U2OS, 143B human osteosarcoma cell lines and human osteoblast cell line hFOB 1.19 |
| Expression Pattern | up-regulated |
| Function Description | a significantly elevated of DNACR was detected in osteosarcoma tissue and cell lines. Functional experiments suggested that down-regulation of DANCR inhibited cells proliferation, migration, invasion and autophagy but induced apoptosis in osteosarcoma in vitro.DANCR was a sponge of miR-216a-5p activity. DANCR regulated survival of osteosarcoma through targeting miR-216a-5p. Additionally, SOX5 was a direct target of miR-216a-5p, overexpression miR-216a-5p exerted inhibition effects via down-regulating SOX5 expression. |
| Pubmed ID | 31918278 |
| Year | 2020 |
| Title | LncRNA DANCR Silence Inhibits SOX5-medicated Progression and Autophagy in Osteosarcoma via Regulating miR-216a-5p |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |