Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | DANCR, AGU2, ANCR, KIAA0114, SNHG13, lncRNA-ANCR |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR etc. |
| Sample | RCC tissues, cell lines (786-O) |
| Expression Pattern | down-regulated |
| Function Description | The results revealed that DANCR is downregulated in RCC tissues compared with adjacent normal tissues. Subsequent study revealed that overexpression of lncRNA DANCR by transfection of pcDNA3.1-DANCR could suppress 786-O and ACHN(RCC cell) proliferation, migration and invasion, and induce apoptosis compared with cells transfected with the pcDNA3.1 vector. The results revealed that DANCR functions as a tumor suppressor in RCC. In conclusion, the present study, to the best of our knowledge, was the frst to reveal DANCR as a tumor suppressor. The results implicate DANCR as a potential biomarker of RCC, and further study will be focused on the clinical signifcance and signaling pathways of DANCR. |
| Pubmed ID | 28765964 |
| Year | 2017 |
| Title | Overexpression of long non-coding RNA differentiation antagonizing non-protein coding RNA inhibits the proliferation, migration and invasion and promotes apoptosis of renal cell carcinoma |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |