Basic Information
| LncRNA/CircRNA Name | DANCR |
| Synonyms | DANCR, AGU2, ANCR, KIAA0114, SNHG13, lncRNA-ANCR |
| Region | GRCh38_4:52712404-52720351 |
| Ensemble | ENSG00000226950 |
| Refseq | NR_024031 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Luciferase reporter assay, Western blot, RNAi |
| Sample | gastric cancer tissues, cell lines (BGC-823, MGC-803,HGC-27 and MKN-45) |
| Expression Pattern | up-regulated |
| Function Description | The expression levels of DANCR were significantly associated with tumor size, TNM stage, lymphatic metastasis and invasion depth. DANCR knockdown inhibited the proliferation of GC cells by inducing cell cycle arrest and cell apoptosis. DANCR knockdown suppressed gastric cancer growth in vivo.DANCR knockdown inhibited the migration and invasion of GC cells via the suppression of epithelial mesenchymal transition (EMT). DANCR is activated by SALL4 in gastric cancer cells and exerted its oncogenic activities through the activation of B-catenin pathway. |
| Pubmed ID | 29416741 |
| Year | 2017 |
| Title | Long noncoding RNA DANCR is activated by SALL4 and promotes the proliferation and invasion of gastric cancer cells. |
External Links
| Links for DANCR | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |