Basic Information
| LncRNA/CircRNA Name | DCST1-AS1 |
| Synonyms | DC-STAMP domain containing 1-antisense 1 |
| Region | GRCh38_1:155045191-155046118 |
| Ensemble | ENSG00000232093 |
| Refseq | NR_040772 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | triple negative breast cancer |
| ICD-0-3 | C50 |
| Methods | Microarray, RT-qPCR, Luciferase reporter assay, Western blotting assay, RIP |
| Sample | TNBC and adjacent normal tissues,TNBC cell lines (MDA-MB-453, BT-549, MDA-MB-231, and HCC1937) and mammary epithelial cell line HBL-100 |
| Expression Pattern | up-regulated |
| Function Description | DCST1-AS1 was up-regulated in both TNBC tissue samples and cell lines. DCST1-AS1 was positively correlated with distant metastasis and histopathological grades. DCST1-AS1 is distributed in both nucleus and cytoplasm. Knockdown of DCST1-AS1 inhibits TNBC cell proliferation and metastasis, while overexpression of DCST1-AS1 promotes TNBC cell proliferation and metastasis. We confirmed that DCST1-AS1 expression in TNBC cells is regulated by MYC. Furthermore, we found that DCST1-AS1 is negatively correlated with miR-873-5p in TNBC tissues and is a direct target gene of miR-873-5p. Argonaute 2 is involved in the binding of DCST1-AS1 and miR-873-5p and promotes the degradation of DCST1-AS1. |
| Pubmed ID | 31897227 |
| Year | 2020 |
| Title | Long Noncoding RNA DCST1-AS1 Promotes Cell Proliferation and Metastasis in Triple-negative Breast Cancer by Forming a Positive Regulatory Loop With miR-873-5p and MYC |
External Links
| Links for DCST1-AS1 | GenBank HGNC NONCODE |
| Links for triple negative breast cancer | OMIM COSMIC |