Basic Information
| LncRNA/CircRNA Name | DGCR5 |
| Synonyms | DiGeorge syndrome critical region gene 5 |
| Region | GRCh38_22:18970514-18994628 |
| Ensemble | ENSG00000237517 |
| Refseq | NR_002733 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | RT-qPCR, Western-Blotting |
| Sample | PC tissues,PC cell lines 22Rv1 and DU145 |
| Expression Pattern | down-regulated |
| Function Description | DGCR5 was down-regulated in tumor tissues than in adjacent healthy tissues of PC patients, but TGF-?1 was up-regulated in the tumor tissues. DGCR5 expression was not affected by clinical stages, but low DGCR5 level in the tumor was correlated with poor survival. DGCR5 and TGF-?1 were inversely correlated in tumor tissues but not in adjacent healthy tissues. DGCR5 over-expression resulted in down-regulation of TGF-?1, while TGF-?1 treatment did not significantly affect DGCR5 expression. DGCR5 over-expression led to decreased stemness of PC cells, but TGF-?1 treatment played a reverse role and attenuated the effects of DGCR5 over-expression. DGCR5 may decrease the stemness of PC cells by down-regulating TGF-?1. |
| Pubmed ID | 31920375 |
| Year | 2019 |
| Title | lncRNA DGCR5 Up-Regulates TGF-?1, Increases Cancer Cell Stemness and Predicts Survival of Prostate Cancer Patients |
External Links
| Links for DGCR5 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |