Basic Information
| LncRNA/CircRNA Name | AF119895 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | Microarray, qPCR, Western blot, Luciferase reporter assay, in vitro knockdown |
| Sample | HCC tissues, HCC cell lines (SMMC7721, Huh7, HepG2 and SK-Hep1) |
| Expression Pattern | up-regulated |
| Function Description | AF119895 promoted migration and invasion of HCC cells both in vitro and in vivo.Furthermore,we identified that NXF3 was a downstream target of AF119895. NXF3 depletion could decrease HCC cells migration and invasion.In addition,AF119895 could act as an endogenous sponge by binding to miR-6508-3p and reduce miR-6508-3p expression. And miR-6508-3p could regulate NXF3 by interacting with its 3'UTR. |
| Pubmed ID | 29274323 |
| Year | 2017 |
| Title | AF119895 regulates NXF3 expression to promote migration and invasion of hepatocellular carcinoma through an interaction with miR-6508-3p. |
External Links
| Links for AF119895 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |