Basic Information
| LncRNA/CircRNA Name | DHRS4-AS1 |
| Synonyms | AS1DHRS4, C14orf167, C14orf67, DHRS4AS1, PRO1488 |
| Region | GRCh38_14:23938731-23988839 |
| Ensemble | ENSG00000215256 |
| Refseq | NR_023921 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | clear cell renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR, Western blot, other |
| Sample | ccRCC tissues and cell lines (786-O, 769-P,HK-2 and 293T) |
| Expression Pattern | down-regulated |
| Function Description | We confirmed the downregulation of DHRS4-AS1 in ccRCC by assessing its expression levels in a cohort of 52 tumor and paired non-tumor samples. In addition, we found that low DHRS4-AS1 expression was significantly associated with a high tumor node metastasis stage, lymph node metastasis, advanced pathological grade and poor prognosis. Furthermore, DHRS4-AS1 overexpression inhibited the progression of cell cycles of ccRCC in vitro. These data indicate that DHRS4-AS1 functions by preventing the proliferation and invasion, inhibiting the cell cycle progression and promoting the apoptosis of ccRCC cells. |
| Pubmed ID | 30254456 |
| Year | 2018 |
| Title | The Downregulated Long Noncoding RNA DHRS4-AS1 Is Protumoral and Associated With the Prognosis of Clear Cell Renal Cell Carcinoma |
External Links
| Links for DHRS4-AS1 | GenBank HGNC NONCODE |
| Links for clear cell renal cell carcinoma | OMIM COSMIC |