Search Result

Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	endometrial cancer
ICD-0-3	NA
Methods	qPCR, Luciferase reporter assay
Sample	endometrial cancer tissues and cell lines (HHUA, KLE, Ishikawa, and ECC-1)
Expression Pattern	up-regulated
Function Description	DLEU1 was upregulated in EC tissues and cells. Suppression of DLEU1 significantly inhibited Ishikawa cell viability, promoted cell apoptosis, decreased BCL-2 expression and increased the expression of Bax, cleaved-caspase-3 and cleaved-caspase-3, suppressed cell migration and invasion, and inhibited EMT via increasing the expression of E-cadherin and decreasing the expression of N-cadherin, Snail and Vimentin. In addition, DLEU1 could sponge miR-490 and miR-490 inhibition significantly reversed the effects of DLEU1 suppression on the malignant behaviors of Ishikawa cells. Furthermore, SP1 was verified as a target of miR-490, and SP1 knockdown could reverse the effects of miR-490 inhibition on the malignant behaviors of Ishikawa cells. Besides, suppression of DLEU1 inhibited PI3K/AKT/GSK-3? pathway, while miR-490 inhibition activated this pathway that could be neutralized by SP1 knockdown.
Pubmed ID	30001771
Year	2018
Title	Long Non-Coding RNA DLEU1 Contributes to the Development of Endometrial Cancer by Sponging miR-490 to Regulate SP1 Expression

External Links