Basic Information
| LncRNA/CircRNA Name | DLEU2 |
| Synonyms | DLEU1, BCMS, BCMS1, DLB1, DLEU2, LEU1, LEU2, LINC00021, NCRNA00021, XTP3 |
| Region | GRCh38_13:49982552-50125720 |
| Ensemble | ENSG00000231607 |
| Refseq | NR_002612 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR |
| Sample | HCC tissues,cell lines |
| Expression Pattern | up-regulated |
| Function Description | HBx and DleU2 co- recruitment on the cccDna displaces eZh2 from the viral chromatin to boost transcription and viral replication. DleU2- hBx association with target host promoters relieves eZh2 repression and leads to the transcriptional activation of a subset of eZh2/Prc2 target genes in hBV- infected cells and hBV- related hccs. |
| Pubmed ID | 32114505 |
| Year | 2020 |
| Title | Hepatitis B protein HBx binds the DLEU2 lncRNA to sustain cccDNA and host cancer- related gene?transcription |
External Links
| Links for DLEU2 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |