Basic Information
| LncRNA/CircRNA Name | DLEU2 |
| Synonyms | DLEU1, BCMS, BCMS1, DLB1, DLEU2, LEU1, LEU2, LINC00021, NCRNA00021, XTP4 |
| Region | GRCh38_13:49982552-50125720 |
| Ensemble | ENSG00000231607 |
| Refseq | NR_002612 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal cancer |
| ICD-0-3 | C15 |
| Methods | RT-PCR, Dual luciferase reporter assay, Western blot assay |
| Sample | EC cell lines Eca-109, KYSE-150 and TE-1 |
| Expression Pattern | up-regulated |
| Function Description | lncRNA DLEU2 was up-regulated in EC tissues and associated with poor prognosis.silencing lncRNA DLEU2 inhibited the proliferation, migration and invasion of EC cells, and induced apoptosis by regulating the Bcl-2/Bax axis and Caspase cascade.Overexpression of lncRNA DLEU2 increased the proliferation, migration and invasion abilities of TE-1 cells, as well as decreased cell apoptosis. |
| Pubmed ID | 31884338 |
| Year | 2020 |
| Title | Long Non-Coding RNA DLEU2 Promotes the Progression of Esophageal Cancer Through miR-30e-5p/E2F7 Axis |
External Links
| Links for DLEU2 | GenBank HGNC NONCODE |
| Links for esophageal cancer | OMIM COSMIC |