Basic Information
| LncRNA/CircRNA Name | DLEU2 |
| Synonyms | DLEU1, BCMS, BCMS1, DLB1, DLEU2, LEU1, LEU2, LINC00021, NCRNA00021, XTP6 |
| Region | GRCh38_13:49982552-50125720 |
| Ensemble | ENSG00000231607 |
| Refseq | NR_002612 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | laryngeal cancer |
| ICD-0-3 | C32 |
| Methods | qPCR, Luciferase reporter assay, in vitro knockdown etc. |
| Sample | cell lines (TU212,A549), laryngeal cancer tissues |
| Expression Pattern | down-regulated |
| Function Description | LncRNA Dleu2 and miR-16-1 levels were significantly declined in the laryngeal carcinoma tissue compared to para-carcinoma tissue.LncRNA Dleu2 and miR-16-1 up-regulation significantly reduced cell proliferation,migration,and invasion compared to the control group.Ago-miR16-1 transfection significantly enhanced the luciferase activity of wild-type Dleu2 compared to control group,suggesting their interaction with each other. LncRNA Dleu2 influences the proliferation, migration, and invasion of laryngeal cancer cells through miR-16-1. Therefore, lncRNA Dleu2 and miR-16-1 may serve as potential biomarkers and targets for laryngeal cancer diagnosis and treatment. |
| Pubmed ID | 29687850 |
| Year | 2018 |
| Title | Long non-coding RNA Dleu2 affects proliferation, migration and invasion ability of laryngeal carcinoma cells through triggering miR-16-1 pathway. |
External Links
| Links for DLEU2 | GenBank HGNC NONCODE |
| Links for laryngeal cancer | OMIM COSMIC |