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Basic Information

Classification Information

Regulatory Mechanism		Biological Function		Clinical Application
TF		Immune		Survival
Enhancer		Apoptosis	apoptosis	Drug
Variant		Cell Growth		Circulating
MiRNA		EMT		Metastasis
Methylation		Coding Ability		Recurrence

Cancer&Entry Information

Cancer Name	breast cancer
ICD-0-3	C50
Methods	qPCR, in vitro knockdown
Sample	breast cancer tissues, cell lines (MCF-7,SK-RB-3,MDA-MB-231??DA-MB-468)
Expression Pattern	up-regulated
Function Description	The expression of AFAP1-AS1 was up-regulated in human breast cancer tissue and associated with malignancy status, high expression of AFAP1-AS1 had a poor prognosis in breast cancer patients. AFAP1-AS1 expression was up-regulated in 4 breast cancer cell lines (MCF-7, SK-RB-3, MDA-MB-231and MDA-MB-468) compared with normal breast cell line HBL-100. MCF-7, the most up-regulation cancer cell, was used for following studies. The EMT-related protein expression was measured, and found AFAP1-AS1 knockdown increased the E-cadherin protein expression, while decreased the N-cadherin and Vimentin protein expression. AFAP1-AS1 knockdown can inhibit the proliferation, metastasis and promote apoptosis of MCF-7. However, the AFAP1 expression and actin filament integrity was not affected after AFAP1-AS1 knockdown.
Pubmed ID	29974352
Year	2018
Title	Up-regulated lncRNA AFAP1-AS1 Indicates a Poor Prognosis and Promotes Carcinogenesis of Breast Cancer

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