Basic Information
| LncRNA/CircRNA Name | DLGAP1-AS2 |
| Synonyms | LncRNA DLGAP1 antisense RNA 2 |
| Region | GRCh38_18:3603000-3608336 |
| Ensemble | ENSG00000262001 |
| Refseq | NR_119377 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | glioma |
| ICD-0-3 | NA |
| Methods | qRT-PCR, western blot |
| Sample | U87 and LN-229 cells |
| Expression Pattern | up-regulated |
| Function Description | LncRNA DLGAP1-AS2 was up-regulated in glioma and was quite correlated with poor prognosis of glioma patients. Depletion of DLGAP1-AS2 in glioma cells could inhibit cell proliferation and cell migration, and induce cell apoptosis, resulting in the suppression of the progression of glioma consequently. Furthermore, knockdown of DLGAP1-AS2 inhibited the growth of xenograft glioma tumour in vivo as well. Finally, we verified Yes Associated Protein 1 (YAP1) was the downstream target of DLGAP1-AS2 and DLGAP1-AS2 modulated glioma cell proliferation, migration and apoptosis via regulating YAP1. |
| Pubmed ID | 31899508 |
| Year | 2020 |
| Title | LncRNA DLGAP1-AS2 Modulates Glioma Development by Up-Regulating YAP1 Expression |
External Links
| Links for DLGAP1-AS2 | GenBank HGNC NONCODE |
| Links for glioma | OMIM COSMIC |