Basic Information
| LncRNA/CircRNA Name | DLX6-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:96955141-97014065 |
| Ensemble | ENSG00000231764 |
| Refseq | NR_015448 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | liver cancer |
| ICD-0-3 | C22.0 |
| Methods | Microarray , qRT-PCR , Luciferase reporter assay , Western blot , RIP etc. |
| Sample | HCC tissues ,HCC cell lines(SMMC-7721, HCCLM3, Hep3B, HepG2 and Huh7) ,immortalized normal L02 liver cell line |
| Expression Pattern | up-regulated |
| Function Description | LncRNA DLX6-AS1 was upregulated in HCC. The silencing of lncRNA DLX6-AS1 was shown to reduce and inhibit spheroid formation, colony formation, proliferation, and tumor formation abilities, as well as attenuate CD133, CD13, OCT-4, SOX2, and Nanog expression in LCSCs.Furthermore, downregulation of lncRNA DLX6-AS1 contributed to a reduction in CADM1 promoter methylation via suppression of DNMT1, DNMT3a, and DNMT3b in LCSCs and inactivating the STAT3 signaling pathway. |
| Pubmed ID | 31171015 |
| Year | 2019 |
| Title | Down-regulated lncRNA DLX6-AS1 Inhibits Tumorigenesis Through STAT3 Signaling Pathway by Suppressing CADM1 Promoter Methylation in Liver Cancer Stem Cells |
External Links
| Links for DLX6-AS1 | GenBank HGNC NONCODE |
| Links for liver cancer | OMIM COSMIC |