Basic Information
| LncRNA/CircRNA Name | DLX6-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:96955141-97014065 |
| Ensemble | ENSG00000231764 |
| Refseq | NR_015448 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | pancreatic cancer |
| ICD-0-3 | C25 |
| Methods | qRT-PCR , Luciferase reporter assay , Western blot , in vitro knockdown etc. |
| Sample | PC tissues and adjacent normal tissues ,normal human pancreatic ductal epithelial cells and PC cell lines(Panc-1, Bxpc-3, AsPC-1, Capan-1, CFPAC-1, and MIA PaCa-2)? |
| Expression Pattern | up-regulated |
| Function Description | DLX6-AS1 was highly expressed in PC tissues and PC cell lines, and was negatively correlated with the survival of PC patients.Overexpression of DLX6-AS1 promoted proliferation, migration, and invasion of PC cells, inhibited apoptosis, increased Bcl-2, cyclin D1, and MMP-2 expression, and decreased cleaved caspase 3, p27, and E-cadherin expression in PC cells.In addition, overexpression of DLX6-AS1 promoted PC growth by increasing tumor volume and weight and increasing the number of liver and lung metastatic foci.Finally, the effect of DLX6-AS1 on proliferation, cell cycle, migration, invasion, and apoptosis of cells and expression of FZD4, FZD6, and ?-catenin was neutralized by overexpression of vectors of miR-497-5p, FZD4, or FZD6, totally or partially. |
| Pubmed ID | 31118816 |
| Year | 2019 |
| Title | Long Noncoding RNA DLX6-AS1 Promotes Tumorigenesis by Modulating miR-497-5p/FZD4/FZD6/Wnt/?-catenin Pathway in Pancreatic Cancer |
External Links
| Links for DLX6-AS1 | GenBank HGNC NONCODE |
| Links for pancreatic cancer | OMIM COSMIC |