Basic Information
| LncRNA/CircRNA Name | DLX6-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:96955141-97014065 |
| Ensemble | ENSG00000231764 |
| Refseq | NR_015448 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qRT-PCR, Western blotting, in vitro knockdown etc. |
| Sample | GC tissue and matched adjacent healthy tissues, normal human gastric mucosa epithelial GES-1 cells and GC cell lines (HGC27, BGC823, SGC7901 and AGS cells) |
| Expression Pattern | up-regulated |
| Function Description | The expression of DLX6-AS1 was significantly upregulated in GC tissues compared with adjacent paired noncancerous tissues.Furthermore, a high expression of DLX6-AS1 was significantly associated with advanced clinical stage, lymph node metastasis and distant metastasis. Compared with patients with a low DLX6-AS1 expression, DLX6-AS1 expression in patients with GC was associated with decreased survival. DLX6-AS1 was upregulated in GC cell lines and that the inhibition of DLX6-AS1 markedly reduced GC cell proliferation, colony formation, cell cycle progression, migration and invasion.Knockdown of DLX6-AS1 inhibited EMT in GC cells. |
| Pubmed ID | 31105791 |
| Year | 2019 |
| Title | Long Non-Coding RNA DLX6-AS1 Silencing Inhibits Malignant Phenotypes of Gastric Cancer Cells |
External Links
| Links for DLX6-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |