Basic Information
| LncRNA/CircRNA Name | DLX6-AS1 |
| Synonyms | NA |
| Region | GRCh38_7:96955141-97014065 |
| Ensemble | ENSG00000231764 |
| Refseq | NR_015448 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot, Luciferase reporter assay, in vitro knockdown, etc. |
| Sample | GC tissue, GC cell lines including MKN-7, MKN-28, MGC-803, HGC-27, MKN-45, AGS and SGC-7901, normal intestinal cell line GES-1 and human embryonic kidney (HEK) cell line 293T |
| Expression Pattern | up-regulated |
| Function Description | We frst demonstrated that DLX6-AS1 was upregulated in GC tissues and cell lines and was associated with T3/T4 invasion, distant metastasis and poor clinical prognosis. Further functional analysis showed that downregulation of DLX6- AS1 inhibited GC cell proliferation, migration, invasion and EMT in vitro. Mechanistic investigation indicated that DLX6- AS1 acted as a cancer-promoting competing endogenous RNA (ceRNA) by binding miR-204-5p and upregulating OCT1. Moreover, the transcription factor OCT1 was confrmed to enhance DLX6-AS1 expression by targeting the promoter region. Conclusions This study revealed that OCT1-induced DLX6-AS1 promoted GC progression and the EMT via the miR204-5p/OCT1 axis, |
| Pubmed ID | 31463827 |
| Year | 2019 |
| Title | DLX6-AS1/miR-204-5p/OCT1 positive feedback loop promotes tumor progression and epithelial-mesenchymal transition in gastric cancer |
External Links
| Links for DLX6-AS1 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |