Basic Information
| LncRNA/CircRNA Name | DMTF1v4 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colon cancer |
| ICD-0-3 | C18 |
| Methods | qPCR, Western blot |
| Sample | colon cancer ticssues, cell lines (HT-29) |
| Expression Pattern | up-regulated |
| Function Description | Compared with para-carcinoma tissue, lncRNA DMTF1v4 in colon cancer tissue was highly expressed (p<0.001). Downregulating lncRNA DMTF1v4 in HT-29 cells showed that lncRNA DMTF1v4 promotes cell proliferation and migration, and suppresses apoptosis (p<0.05). The effect of lncRNA DMTF1v4 on the ERK/MAPK signaling pathway was evaluated. The expression of p-ERK, p-JNK, and p-p38 was increased significantly compared with the control group (p<0.01). Compared with the control group, the cell survival rate in the DMTF1v4-siR-NA group was significantly decreased. The effect of downregulating DMTF1v4 on tumor growth in animals showed that tumor growth in nude mice was decreased, and the expression of apoptosis-related proteins was increased (p<0.01). |
| Pubmed ID | 29949153 |
| Year | 2018 |
| Title | Study on the Function and Mechanism of Long Non-Coding RNA DMTF1v4 in the Occurrence of Colon Cancer |
External Links
| Links for DMTF1v4 | GenBank HGNC NONCODE |
| Links for colon cancer | OMIM COSMIC |