Basic Information
| LncRNA/CircRNA Name | DNM3OS |
| Synonyms | DNM3OS, DNM3-AS1, MIR199A2HG |
| Region | GRCh38_1:172136531-172144794 |
| Ensemble | ENSG00000230630 |
| Refseq | NR_038397 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot, Luciferase assay, other |
| Sample | ESCC tissues and cell lines(cells KYSE-30, KYSE-140,137 KYSE-150, KYSE-180 and KYSE-450) |
| Expression Pattern | up-regulated |
| Function Description | CAFs promoted the expression of DNM3OS in a PDGF?/PDGFR?/FOXO1 signaling pathway-dependent manner. FOXO1, a transcription factor downstream of PDGF?/PDGFR? signaling pathway, initiated the transcription of DNM3OS by binding to DNM3OS promoter. |
| Pubmed ID | 30463848 |
| Year | 2019 |
| Title | Cancer-associated Fibroblast-promoted LncRNA DNM3OS Confers Radioresistance by Regulating DNA Damage Response in Esophageal Squamous Cell Carcinoma |
External Links
| Links for DNM3OS | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |