Basic Information
| LncRNA/CircRNA Name | DNM3OS |
| Synonyms | DNM3OS, DNM3-AS1, MIR199A2HG |
| Region | GRCh38_1:172136531-172144794 |
| Ensemble | ENSG00000230630 |
| Refseq | NR_038397 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | epithelial ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR etc. |
| Sample | cell lines (type I, type II etc.) |
| Expression Pattern | up-regulated |
| Function Description | The characterization of Twist1 as a regulator of a unique miRNA cluster responsible for the regulation of the IKKb/NFkB and PTEN/AKT pathways and its association of ovarian CSC differentiation. Our data suggest that Twist1 may be an important regulator of 'stemness' in EOC cells. The regulation of MIR199A2/214 expression may be used as a potential therapeutic approach in EOC patients. |
| Pubmed ID | 20400975 |
| Year | 2010 |
| Title | TWISTing stemness, inflammation and proliferation of epithelial ovarian cancer cells through MIR199A2/214. |
External Links
| Links for DNM3OS | GenBank HGNC NONCODE |
| Links for epithelial ovarian cancer | OMIM COSMIC |