Basic Information
| LncRNA/CircRNA Name | DQ786243 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, RIP |
| Sample | hepatocellular carcinoma tissues, cell lines (Huh-7, HepG2, HepG3B, SMMC7721, L02) |
| Expression Pattern | up-regulated |
| Function Description | LncDQ was upregulated in both HCC tissue samples and serum and was correlated with low survival rate and adverse clinical pathological characteristics.LncDQ expression was an independent prognostic factor for HCC. Knockdown of LncDQ induced inhibition of cell proliferation, migration, and invasion in vitro and in vivo.LncDQ regulated the epithelial-mesenchymal transition pathway by interacting with EZH2, to epigenetically repress the expression of E-cadherin in HCC cells. |
| Pubmed ID | 29669339 |
| Year | 2018 |
| Title | Upregulation of LncDQ is Associated with Poor Prognosis and Promotes Tumor Progression via Epigenetic Regulation of the EMT Pathway in HCC. |
External Links
| Links for DQ786243 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |