Basic Information
| LncRNA/CircRNA Name | DSCAM-AS1 |
| Synonyms | NA |
| Region | GRCh38_21:40383083-40385358 |
| Ensemble | ENSG00000235123 |
| Refseq | NR_038896 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal adenocarcinoma |
| ICD-0-3 | NA |
| Methods | RT-qPCR |
| Sample | primary tumor tissues,cells of human CRA cell lines WiDr and HT-29 |
| Expression Pattern | up-regulated |
| Function Description | DSCAM-AS1 was upregulated in the primary tumor tissues than in paired non-tumor tissues and was further increased with tumor metastasis.DSCAM-AS1 overexpression did not significantly affect cancer cell proliferation but promoted cell migration and invasion.Methylation-specific PCR showed that DSCAM-AS1 overexpression promoted the methylation of miR-216b gene. |
| Pubmed ID | 31686837 |
| Year | 2019 |
| Title | lncRNA DSCAM-AS1 Downregulates miR-216b to Promote the Migration and Invasion of Colorectal Adenocarcinoma Cells |
External Links
| Links for DSCAM-AS1 | GenBank HGNC NONCODE |
| Links for colorectal adenocarcinoma | OMIM COSMIC |