Basic Information
| LncRNA/CircRNA Name | DSCAM-AS1 |
| Synonyms | NA |
| Region | GRCh38_21:40383083-40385358 |
| Ensemble | ENSG00000235123 |
| Refseq | NR_038896 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | melanoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Luciferase reporter assay , in vitro knockdown etc. |
| Sample | melanoma and corresponding non-cancerous tissues ,human melanoma cells lines (1205Lu,CHL-1, A-375, UACC903, and SK-MEL-2) and normal human epidermal melanocyte (HEMa-LP) |
| Expression Pattern | up-regulated |
| Function Description | The expression of DSCAM-AS1 was significantly upregulated in melanoma samples and cell lines.Higher expression of DSCAM-AS1 was associated with ulceration and advanced stage and led to significantly poorer survival time.High DSCAM-AS1 expression in melanoma was confirmed to be an independent predictor of poor survival of patients.Knockdown of DSCAM-AS1 inhibited the ability of cell proliferation, colony formation, migration, invasion, whereas promoted cell apoptosis.DSCAM-AS1 could interact with miR-136 and negatively influence the expression of miR-136. |
| Pubmed ID | 31002140 |
| Year | 2019 |
| Title | Long Noncoding RNA DSCAM-AS1 Is Associated With Poor Clinical Prognosis and Contributes to Melanoma Development by Sponging miR-136 |
External Links
| Links for DSCAM-AS1 | GenBank HGNC NONCODE |
| Links for melanoma | OMIM COSMIC |