Basic Information
| LncRNA/CircRNA Name | DSCAM-AS1 |
| Synonyms | DSCAM-AS1, M41 |
| Region | GRCh38_21:40383083-40385358 |
| Ensemble | ENSG00000235123 |
| Refseq | NR_038896 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RNA-seq, qPCR, other |
| Sample | BRCA tissues and cell lines(MCF-7,T-47D) |
| Expression Pattern | up-regulated |
| Function Description | RNA-seq analysis demonstrated that DSCAM-AS1 participates in crucial biological processes, including DNA replication, the G1/S phase transition, sister chromatid cohesion, chromosome segregation, protein localization to the chromosome and DNA recombination. Most importantly, in the retrospectively registered clinical analysis, high expression of DSCAM-AS1 is a poor prognostic factor in patients with luminal breast cancer treated with endocrine therapy. |
| Pubmed ID | 30430768 |
| Year | 2018 |
| Title | DSCAM-AS1 Regulates the G 1 /S Cell Cycle Transition and Is an Independent Prognostic Factor of Poor Survival in Luminal Breast Cancer Patients Treated With Endocrine Therapy |
External Links
| Links for DSCAM-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |