Basic Information
| LncRNA/CircRNA Name | DSCAM-AS1 |
| Synonyms | DSCAM-AS1, M41 |
| Region | GRCh38_21:40383083-40385358 |
| Ensemble | ENSG00000235123 |
| Refseq | NR_038896 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | RNA-seq, qPCR, RNAi, ChIP, Cell proliferation assay etc. |
| Sample | cell lines (MCF-7, HEK 293T, MDA-MB-231, SK-BR-3 etc.) |
| Expression Pattern | up-regulated |
| Function Description | The most abundant AER-lncRNA, DSCAM-AS1, is expressed in ERa+ breast carcinoma, but not in pre-neoplastic lesions, and correlates inversely with EMT markers. Down-regulation of DSCAM-AS1 recapitulated, in part, the effect of silencing ERa, i.e. growth arrest and induction of EMT markers. |
| Pubmed ID | 26621851 |
| Year | 2016 |
| Title | Luminal long non-coding RNAs regulated by estrogen receptor alpha in a ligand-independent manner show functional roles in breast cancer. |
External Links
| Links for DSCAM-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |