Basic Information
| LncRNA/CircRNA Name | DSCR8 |
| Synonyms | NA |
| Region | GRCh38_21:38121451-38156511 |
| Ensemble | ENSG00000198054 |
| Refseq | NR_026838 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | hepatocellular carcinoma |
| ICD-0-3 | C22.0 |
| Methods | qPCR, Western blot, RIP, Luciferase reporter assay |
| Sample | hepatocellular carcinoma tissues, cell lines (MHCC-97 L, HepG2, Hep3B, Huh7, SMMC-7721, LO2) |
| Expression Pattern | up-regulated |
| Function Description | DSCR8 expression was upregulated. DSCR8 promoted HCC cell proliferation and cycle, whereas accelerated cell apoptosis, DSCR8 functioned as a competing endogenous RNA (ceRNA) by sponging miR-485-5p in HCC cells. DSCR8 and miR-485-5p were closely related to some malignant clinicopathological features and 5-year survival rates of HCC patients. DSCR8 was closely related to tumor size (P=0.015) and tumor-node-metastasis (TNM) stage. |
| Pubmed ID | 30154476 |
| Year | 2018 |
| Title | Long non-coding RNA DSCR8 acts as a molecular sponge for miR-485-5p to activate Wnt/?-catenin signal pathway in hepatocellular carcinoma. |
External Links
| Links for DSCR8 | GenBank HGNC NONCODE |
| Links for hepatocellular carcinoma | OMIM COSMIC |