Basic Information
| LncRNA/CircRNA Name | DUXAP8 |
| Synonyms | pseudogene 8 |
| Region | GRCh38_22:15784959-15829984 |
| Ensemble | ENSG00000206195 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Luciferase reporter assay etc |
| Sample | NSCLC tissues and adjacent normal tissues,NSCLC cell lines (H460, H520, A549,H1975,BEAS-2B) |
| Expression Pattern | up-regulated |
| Function Description | DUXAP8 and TRIM44 were upregulated in NSCLC tissues and cell lines, while miR-498 was downregulated. Functionally, knockdown of DUXAP8 could repress proliferation, migration, invasion, Epithelial-Mesenchymal Transition (EMT) and phosphorylation of AKT/mTOR in NSCLC cells |
| Pubmed ID | 32271433 |
| Year | 2020 |
| Title | Down-regulation of Long Non-Coding RNA DUXAP8 Suppresses Proliferation, Metastasis and EMT by Modulating miR-498 Through TRIM44-mediated AKT/mTOR Pathway in Non-Small-Cell Lung Cancer |
External Links
| Links for DUXAP8 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |