Basic Information
| LncRNA/CircRNA Name | EGOT |
| Synonyms | EGOT, EGO, NCRNA00190 |
| Region | GRCh38_3:4749192-4751590 |
| Ensemble | ENSG00000235947 |
| Refseq | NR_004428 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | renal cell carcinoma |
| ICD-0-3 | C64.9 |
| Methods | qPCR etc. |
| Sample | RCC tissues, cell lines (786-O, ACHN) |
| Expression Pattern | up-regulated |
| Function Description | The expression and function of lncRNA eosinophil granule ontogeny transcript(EGOT) were examined in RCC. In 24 paired tissues (RCC tissues and adjacent normal tissues) the results of reverse transcription-quantitative polymerase chain reaction analysis revealed that EGOT was downregulated in 22 RCC tissues compared with paired tissues. Upregulation of lncRNA EGOT by transfection of 786-O and ACHN RCC cells with pcDNA3.1-EGOT suppressed cell proliferation, migration and invasion, and induced RCC cell apoptosis. The results demonstrated that EGOT may serve as a tumor suppressor in RCC and may be a potential prognostic biomarker of RCC. |
| Pubmed ID | 28901455 |
| Year | 2017 |
| Title | Identifcation of lncRNA EGOT as a tumor suppressor in renal cell carcinoma |
External Links
| Links for EGOT | GenBank HGNC NONCODE |
| Links for renal cell carcinoma | OMIM COSMIC |