Basic Information
| LncRNA/CircRNA Name | AFAP1-AS1 |
| Synonyms | actin filagenin 1 antisense RNA 1 |
| Region | GRCh38_4:7754090-7778928 |
| Ensemble | ENSG00000272620 |
| Refseq | NR_026892 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qRT-PCR, RIP, Luciferase reporter gene assay, Western blot |
| Sample | normal myofibroblast stromal cell lines and human PCA cell lines,tumor specimens |
| Expression Pattern | up-regulated |
| Function Description | AFAP1-AS1 is highly expressed in prostate cancer tissues and cell lines. The expression level of AFAP1-AS1 is correlated with histological grade and distant metastasis. The overall level of patients with high expression of AFAP1-AS1 is low, and their survival rate is relatively low. Silencing AFAP1-AS1 can significantly increase the proliferation and migration of prostate cancer cells. AFAP1-AS1 silencing induces cell cycle arrest at G0/G1 phase. |
| Pubmed ID | 31669642 |
| Year | 2020 |
| Title | Long Non-Coding RNA AFAP1-AS1 Promotes Proliferation and Invasion in Prostate Cancer via Targeting miR-512-3p |
External Links
| Links for AFAP1-AS1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |