Basic Information
| LncRNA/CircRNA Name | EINCR1 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | lung adenocarcinoma |
| ICD-0-3 | C34 |
| Methods | qPCR etc. |
| Sample | cell lines (MCF10A, A549, MCF7, MDA-MD-231 and HEK293T) |
| Expression Pattern | up-regulated |
| Function Description | EINCR1 is specifically expressed in normal human heart tissues and is up-regulated in cancer. in several cancers EINCR1 shows elevated expression levels which correlate with poor survival in lung adenocarcinoma patients. In the context of lung adenocarcinomas, EINCR1 expression is anti-correlated with the expression of several protein coding EGF-regulated genes. A potential functional connection is demonstrated as EINCR1 overexpression is shown to reduce the expression of EGF-regulated protein coding genes including FOS and FOSB. |
| Pubmed ID | 28732076 |
| Year | 2017 |
| Title | EINCR1 is an EGF inducible lincRNA overexpressed in lung adenocarcinomas. |
External Links
| Links for EINCR1 | GenBank HGNC NONCODE |
| Links for lung adenocarcinoma | OMIM COSMIC |