Basic Information
| LncRNA/CircRNA Name | ELF3-AS1 |
| Synonyms | ELF3-antisense RNA 1 |
| Region | GRCh38_1:202000094-202010353 |
| Ensemble | ENSG00000234678 |
| Refseq | NR_146472 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qPCR, Western blot etc |
| Sample | OS tissues,cell line (U2OS) |
| Expression Pattern | up-regulated |
| Function Description | ELF3-AS1 was upregulated in OS tissues, and ELF3-AS1 expression level increased with increasing clinical stage. In OS tissues, Kruppel-like factor 12 (KLF12) was positively correlated with ELF3-AS1, while microRNA (miR)-205 was negatively correlated with ELF3-AS1. ELF3-AS1 overexpression resulted in the upregulation of KLF12, but the downregulation of miR-205. Overexpression of miR-205 caused downregulation of KLF12, but had no significant effects on ELF3-AS1 expression. |
| Pubmed ID | 32194747 |
| Year | 2020 |
| Title | Long Non-Coding RNA ELF3-antisense RNA 1 Promotes Osteosarcoma Cell Proliferation by Upregulating Kruppel-like Factor 12 Potentially via Methylation of the microRNA-205 Gene |
External Links
| Links for ELF3-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |