Basic Information
| LncRNA/CircRNA Name | AFAP1-AS1 |
| Synonyms | NA |
| Region | GRCh38_4:7754090-7778928 |
| Ensemble | ENSG00000272620 |
| Refseq | NR_026892 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | prostate cancer |
| ICD-0-3 | C61.9 |
| Methods | qRT-PCR , Western blot , in vitro knockdown etc. |
| Sample | prostate cancer and normal tissues , prostate cancer cell lines(PC3, LNCaP,DU145),normal prostate epithelial cell lines P69 |
| Expression Pattern | up-regulated |
| Function Description | The expression level of AFAP1-AS1 was significantly higher in prostate cancer samples than that in corresponding ones.Additionally, the cell proliferation, migration, and invasion capacities were inhibited after AFAP1-AS1 was knocked down in prostate cancer cells.Moreover, the mRNA and protein expressions of RBM5 were upregulated after AFAP1-AS1 was knocked down. Furthermore, the RBM5 expression level was negatively related to AFAP1-AS1 expression level in prostate cancer samples.AFAP1-AS1 acts as an oncogene in prostate cancer by enhancing cell metastasis and proliferation via suppressing RBM5. |
| Pubmed ID | 31081081 |
| Year | 2019 |
| Title | Long Noncoding RNA AFAP1-AS1 Accelerates the Proliferation and Metastasis of Prostate Cancer via Inhibiting RBM5 Expression |
External Links
| Links for AFAP1-AS1 | GenBank HGNC NONCODE |
| Links for prostate cancer | OMIM COSMIC |