Basic Information
| LncRNA/CircRNA Name | AFAP1-AS1 |
| Synonyms | NA |
| Region | GRCh38_4:7754090-7778928 |
| Ensemble | ENSG00000272620 |
| Refseq | NR_026892 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | osteosarcoma |
| ICD-0-3 | NA |
| Methods | qRT-PCR , Western blot , RIP etc. |
| Sample | osteosarcoma and adjacent non-tumor tissues ,human osteosarcoma cell lines(MG-63, U2OS,Saos-2 and SOSP-9607) and osteoblastic cell line hFOB 1.19 |
| Expression Pattern | up-regulated |
| Function Description | The expression level of AFAP1-AS1 was higher in osteosarcoma samples than that in adjacent tissues.In addition, the proliferation and invasion were inhibited after AFAP1-AS1 was downregulated in vitro. Besides, the mRNA and protein expression levels of brain derived neurotrophic factor (BDNF) were reduced after downregulation of AFAP1-AS1. Furthermore, the expression level of BDNF was positively related to the expression of AFAP1-AS1 in osteosarcoma tissues. |
| Pubmed ID | 31002124 |
| Year | 2019 |
| Title | Long Noncoding RNA AFAP1-AS1 Promoted Osteosarcoma Proliferation and Invasion via Upregulating BDNF |
External Links
| Links for AFAP1-AS1 | GenBank HGNC NONCODE |
| Links for osteosarcoma | OMIM COSMIC |