Basic Information
| LncRNA/CircRNA Name | ENST00000434223 |
| Synonyms | NA |
| Region | GRCh38_15:38069481-38072959 |
| Ensemble | ENSG00000236914 |
| Refseq | NR_147199 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | gastric cancer |
| ICD-0-3 | C16 |
| Methods | qPCR, Western blot |
| Sample | gastric cancer tissues, cell lines (BGC823, AGS, MKN-45, SGC-7901, MKN-28) |
| Expression Pattern | down-regulated |
| Function Description | expression of ENST00000434223 and E-cadherin was decreased. the rate of apoptosis was decreased and cell proliferation, invasion and migration were increased in response to downregulation of ENST00000434223. ENST00000434223 inhibits activation of Wnt/?-catenin signaling and suppresses EMT in SGC-7901 and MKN-45 cells. |
| Pubmed ID | 30138664 |
| Year | 2018 |
| Title | Long non-coding RNA-ENST00000434223 suppresses tumor progression in gastric cancer cells through the Wnt/?-catenin signaling pathway. |
External Links
| Links for ENST00000434223 | GenBank HGNC NONCODE |
| Links for gastric cancer | OMIM COSMIC |