Basic Information
| LncRNA/CircRNA Name | ENST00000434223 |
| Synonyms | LINC01852 |
| Region | GRCh38_15:38071627-38072683 |
| Ensemble | ENSG00000236914 |
| Refseq | NR_147199 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, Flow cytometry assay etc. |
| Sample | cell lines (SK-MES-1, SPC-A1, A549, NCI-H1975 and 16HBE) |
| Expression Pattern | down-regulated |
| Function Description | we found that ENST00000434223 was greatly downregulated in cancer tissues compared to adjacent normal tissues. ENST00000434223 overexpression suppressed the proliferation and migration in NSCLC cell lines in vitro. Moreover, ENST00000434223 overexpression reversed the epithelial-mesenchymal transition in NSCLC cell line |
| Pubmed ID | 26883250 |
| Year | 2016 |
| Title | Long noncoding RNA ENST00000434223 suppressed tumor progression in non-small cell lung cancer |
External Links
| Links for ENST00000434223 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |