Basic Information
| LncRNA/CircRNA Name | ENST00000457645 |
| Synonyms | NA |
| Region | NA |
| Ensemble | NA |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | Cisplatin | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | Microarray, qPCR, Cell transfection, Western blot etc. |
| Sample | cell lines (A2780, CP70, SKOV3, and SKOV3/DDP) |
| Expression Pattern | down-regulated |
| Function Description | The lncRNA microarray analysis and qPCR identified seven lncRNAs that were significantly downregulated. Transfection of lncRNA ENST00000457645 into CP70 cells markedly inhibited viability and migration ability, and significantly increased expression of apoptotic proteins such as Bax and cleaved caspase-3. lncRNA ENST00000457645 negatively affects the viability and migration of cisplatin-resistant CP70 ovarian cancer cells. |
| Pubmed ID | 28128423 |
| Year | 2017 |
| Title | Long non-coding RNA ENST00000457645 reverses cisplatin resistance in CP70 ovarian cancer cells. |
External Links
| Links for ENST00000457645 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |