Basic Information
| LncRNA/CircRNA Name | EPB41L4A-AS2 |
| Synonyms | NA |
| Region | GRCh38_5:112419583-112420978 |
| Ensemble | ENSG00000278921 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | non small cell lung cancer |
| ICD-0-3 | C34 |
| Methods | qPCR, Western blot, other |
| Sample | NSCLC tissues and cell lines (SK-MES-1), lung adenocarcinoma cell lines (HCC827, A549 and NCI-H1975) |
| Expression Pattern | down-regulated |
| Function Description | EPB41L4A-AS2 expression was significantly downregulated in cancer tissues and cells compared with the adjacent tissues and normal cells (P<0.05). After cells were transfected with pcDNA3.1-EPB41L4A-AS2, cell viability and PCNA protein level was decreased, and cells were arrested in the G0/G1 phase with higher apoptosis rate. Transwell assay showed that over-expressed EPB41L4A-AS2 could reduce cells invasion ability. Expression of low levels of EPB41L4A-AS2 is associated with poor survival in NSCLC and the over-expression of lncRNA EPB41L4A-AS2 inhibits NSCLC cell proliferation, invasion and promote cell apoptosis. |
| Pubmed ID | 30249102 |
| Year | 2018 |
| Title | Long Non-Coding RNA EPB41L4A-AS2 Inhibited Non-Small Cell Lung Cancer Proliferation, Invasion and Promoted Cell Apoptosis |
External Links
| Links for EPB41L4A-AS2 | GenBank HGNC NONCODE |
| Links for non small cell lung cancer | OMIM COSMIC |