Basic Information
| LncRNA/CircRNA Name | EPB41L4A-AS2 |
| Synonyms | NA |
| Region | GRCh38_5:112419583-112420978 |
| Ensemble | ENSG00000278921 |
| Refseq | NA |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | ovarian cancer |
| ICD-0-3 | C56.9 |
| Methods | qPCR, Western blot, Luciferase reporter assay, RIP |
| Sample | Normal human ovarian epithelial cell line HOSEpiC, OC cell lines HO-8910, OV-90, OVCAR-3, SK-OV-3, Human OC tissues and matched paracancerous tissues |
| Expression Pattern | down-regulated |
| Function Description | EPB41L4A-AS2 was poorly expressed in OC tissues and cells, and then microarray data revealed the upregulation of miR-103a and downregulation of RUNX1T1 in OC. RUNX1T1 was a target gene of miR-103a, and EPB41L4A-AS2 bound to miR-103a. Moreover, EPB41L4A-AS2 increased RUNX1T1 expression by decreasing miR-103a expression. EPB41L4A-AS2-overexpressed SK-OV-3 cells exhibited inhibited proliferation, migration, colony formation and invasion of OC cells, which was rescued by overexpressed miR-103a or silencing of RUNX1T1. Besides, overexpressed EPB41L4A-AS2 repressed the tumor formation in vivo. |
| Pubmed ID | 31645082 |
| Year | 2019 |
| Title | Long non-coding RNA EPB41L4A-AS2 suppresses progression of ovarian cancer by sequestering microRNA-103a to upregulate transcription factor RUNX1T1 |
External Links
| Links for EPB41L4A-AS2 | GenBank HGNC NONCODE |
| Links for ovarian cancer | OMIM COSMIC |