Basic Information
| LncRNA/CircRNA Name | Epist |
| Synonyms | C5orf66-AS1, CTC-276P9.1, Epist |
| Region | GRCh38_5:135038831-135040047 |
| Ensemble | ENSG00000249082 |
| Refseq | NR_105049 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR etc. |
| Sample | cell lines (KYSE510, KYSE450, KYSE150, KYSE30, EC109, TE-1) |
| Expression Pattern | down-regulated |
| Function Description | We identified a novel nuclear-retained lncRNA, named Epist, which is generally highly expressed in esophagus, and which is down-regulated during ESCC progression. Epist over-expression and knockdown studies further suggest that Epist inhibits the metastasis, acting as a tumor suppressor in ESCC. Collectively |
| Pubmed ID | 26158411 |
| Year | 2015 |
| Title | Transcriptome profiling of esophageal squamous cell carcinoma reveals a long noncoding RNA acting as a tumor suppressor |
External Links
| Links for Epist | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |