Basic Information
| LncRNA/CircRNA Name | ESCCAL_1 |
| Synonyms | CASC9, ESCCAL-1, ESSCAL1, LINC00981 |
| Region | GRCh38_8:75223404-75324741 |
| Ensemble | ENSG00000249395 |
| Refseq | NR_103848 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | esophageal squamous cell carcinoma |
| ICD-0-3 | NA |
| Methods | Western blot |
| Sample | esophageal squamous cell carcinoma tissues |
| Expression Pattern | down-regulated |
| Function Description | ESCCAL_1 knockdown significantly inhibited EC9706 cell growth in nude mice.reduced expression of ESCCAL_1 resulted in distinct alterations of relative phosphorylation level of kinases (p-p38a, p-JNK, p-FAK and p-Src), and significant changes of the expression level of apoptosis-related proteins (p53,BAX, Bcl-2 and Caspase-3).Over-expression of ESCCAL_1 activates survival pathway and decrease apoptosis. |
| Pubmed ID | 29416654 |
| Year | 2017 |
| Title | Down-regulation of long non-coding RNA ESCCAL_1 inhibits tumor growth of esophageal squamous cell carcinoma in a xenograft mouse model. |
External Links
| Links for ESCCAL_1 | GenBank HGNC NONCODE |
| Links for esophageal squamous cell carcinoma | OMIM COSMIC |