Basic Information
| LncRNA/CircRNA Name | EWSAT1 |
| Synonyms | EWSAT1, LINC00277, NCRNA00277, TMEM84 |
| Region | GRCh38_15:69072926-69095820 |
| Ensemble | ENSG00000212766 |
| Refseq | NR_026949 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | Drug | |||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | Ewing sarcoma |
| ICD-0-3 | NA |
| Methods | Microarray, qPCR, Western blot, RIP etc. |
| Sample | cell lines (pMPCs, PSS090 and TC71) |
| Expression Pattern | up-regulated |
| Function Description | Expression of EWS-FLI1 and EWSAT1 repressed gene expression, and a substantial fraction of targets that were repressed by EWS-FLI1 were also repressed by EWSAT1. Analysis of RNAseq data from primary human Ewing sarcoma further supported a role for EWSAT1 in mediating gene repression. We identified heterogeneous nuclear ribonucleoprotein (HNRNPK) as an RNA-binding protein that interacts with EWSAT1 and found a marked overlap in HNRNPK-repressed genes and those repressed by EWS-FLI1 and EWSAT1, suggesting that HNRNPK participates in EWSAT1-mediated gene repression. |
| Pubmed ID | 25401475 |
| Year | 2014 |
| Title | Long noncoding RNA EWSAT1-mediated gene repression facilitates Ewing sarcoma oncogenesis |
External Links
| Links for EWSAT1 | GenBank HGNC NONCODE |
| Links for Ewing sarcoma | OMIM COSMIC |