Basic Information
| LncRNA/CircRNA Name | EZR-AS1 |
| Synonyms | ezrin antisense RNA 1 |
| Region | GRCh38_6:158818011-158820593 |
| Ensemble | ENSG00000233893 |
| Refseq | NR_102425 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | colorectal cancer |
| ICD-0-3 | C19.9 |
| Methods | qRT-PCR, Western blot |
| Sample | CRC cell lines, HCT8, HCT116, HT29, and SW620, which are with different origins and genetic characteristics, and FHC, a normal human fetal colonic mucosa cell line |
| Expression Pattern | up-regulated |
| Function Description | lncRNA EZR-AS1 is an oncogene that up-regulated in CRC cells. Silencing of lncRNA EZR-AS1 inhibits the proliferation, invasion, migration, and EMT, and promotes the apoptosis of CRC cells through blocking TGF-? signaling. Because silencing of EZR-AS1 also inhibits the tumor growth in vivo (mice), EZR-AS1 is a promising therapeutic target for CRC. |
| Pubmed ID | 31693738 |
| Year | 2019 |
| Title | Silencing of lncRNA EZR-AS1 Inhibits Proliferation, Invasion, and Migration of Colorectal Cancer Cells Through Blocking Transforming Growth Factor ? Signaling |
External Links
| Links for EZR-AS1 | GenBank HGNC NONCODE |
| Links for colorectal cancer | OMIM COSMIC |