Basic Information
| LncRNA/CircRNA Name | EZR-AS1 |
| Synonyms | NA |
| Region | GRCh38_6:158818011-158820593 |
| Ensemble | ENSG00000233893 |
| Refseq | NR_102425 |
Classification Information
| Regulatory Mechanism | Biological Function | Clinical Application | |||
|---|---|---|---|---|---|
| TF | Immune | Survival | |||
| Enhancer | Apoptosis | apoptosis | Drug | ||
| Variant | Cell Growth | Circulating | |||
| MiRNA | EMT | Metastasis | |||
| Methylation | Coding Ability | Recurrence |
Cancer&Entry Information
| Cancer Name | breast cancer |
| ICD-0-3 | C50 |
| Methods | qPCR, Western blot, RIP |
| Sample | breast cancer tissues, cell lines (MCF7, MDA-MB-231, MDA-MB-468, SKBR-3, MCF-10A) |
| Expression Pattern | up-regulated |
| Function Description | the expression of EZR-AS1 was signifi-cantly upregulated in BC tissues and cell lines. increased EZR-AS1 expression in patients with BC contributes to poor prognosis. t EZR-AS1 knockdown significantly suppressed the proliferation and cell cycle progression of breast cancer cells while reducing cellular apoptosis. EZR-AS1 knockdown reduced the migration and invasion ability of BC cells compared with control cells. |
| Pubmed ID | 30186463 |
| Year | 2018 |
| Title | Long noncoding RNA EZR-AS1 promotes tumor growth and metastasis by modulating Wnt/?-catenin pathway in breast cancer. |
External Links
| Links for EZR-AS1 | GenBank HGNC NONCODE |
| Links for breast cancer | OMIM COSMIC |